{"id":899,"date":"2026-06-01T12:07:56","date_gmt":"2026-06-01T03:07:56","guid":{"rendered":"https:\/\/stemcells.jp\/topics\/?p=899"},"modified":"2026-06-01T12:07:56","modified_gmt":"2026-06-01T03:07:56","slug":"intrathecal-huc-msc-exosomes-spinal-cord-injury-study","status":"publish","type":"post","link":"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/","title":{"rendered":"\u810a\u9ac4\u640d\u50b7\u306b\u5bfe\u3059\u308bMSC\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6cbb\u7642\u306e\u53ef\u80fd\u6027 \u2015 \u7b2cI\u76f8\u81e8\u5e8a\u8a66\u9a13\u3088\u308a"},"content":{"rendered":"<p>HELENE CLINIC \u5b66\u8853\u8ad6\u6587\u8981\u7d04\u30b7\u30ea\u30fc\u30ba<\/p>\n<p>Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury<\/p>\n<p>Stem Cell Res Ther | 2024 Aug 26 | Akhlaghpasand M et al.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_36_1 counter-hierarchy ez-toc-counter ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#Abstract%EF%BC%88Abstract%E3%81%AE%E6%97%A5%E6%9C%AC%E8%AA%9E%E8%A8%B3%EF%BC%89\" title=\"Abstract\uff08Abstract\u306e\u65e5\u672c\u8a9e\u8a33\uff09\">Abstract\uff08Abstract\u306e\u65e5\u672c\u8a9e\u8a33\uff09<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#Objective\" title=\"Objective\">Objective<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#Methods\" title=\"Methods\">Methods<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#Results\" title=\"Results\">Results<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#%E5%8E%9F%E8%91%97%E6%83%85%E5%A0%B1\" title=\"\u539f\u8457\u60c5\u5831\">\u539f\u8457\u60c5\u5831<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#HELENE_%E5%8C%BB%E5%B8%AB%E3%81%AE%E8%A6%8B%E8%A7%A3\" title=\"HELENE \u533b\u5e2b\u306e\u898b\u89e3\">HELENE \u533b\u5e2b\u306e\u898b\u89e3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/stemcells.jp\/topics\/intrathecal-huc-msc-exosomes-spinal-cord-injury-study\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE%E3%83%BB%E9%96%A2%E9%80%A3%E8%B3%87%E6%96%99\" title=\"\u53c2\u8003\u6587\u732e\u30fb\u95a2\u9023\u8cc7\u6599\">\u53c2\u8003\u6587\u732e\u30fb\u95a2\u9023\u8cc7\u6599<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Abstract%EF%BC%88Abstract%E3%81%AE%E6%97%A5%E6%9C%AC%E8%AA%9E%E8%A8%B3%EF%BC%89\"><\/span>Abstract\uff08Abstract\u306e\u65e5\u672c\u8a9e\u8a33\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Objective\"><\/span>Objective<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u810a\u9ac4\u640d\u50b7\uff08SCI\uff09\u60a3\u8005\u3067\u306f\u3001\u640d\u50b7\u3057\u305f\u8ef8\u7d22\u306e\u518d\u751f\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u305f\u3081\u3001\u795e\u7d4c\u5b66\u7684\u969c\u5bb3\u304a\u3088\u3073\u6a5f\u80fd\u969c\u5bb3\u304c\u4e00\u822c\u7684\u306b\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u306e\u30d1\u30e9\u30af\u30e9\u30a4\u30f3\u4f5c\u7528\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001SCI\u306b\u5bfe\u3059\u308b\u6709\u671b\u306a\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u672c\u7814\u7a76\u3067\u306f\u3001\u5b8c\u5168\u6027\u4e9c\u6025\u6027\u671f\u810a\u9ac4\u640d\u50b7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u3001\u30d2\u30c8\u81cd\u5e2f\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08HUC-MSC\uff09\u7531\u6765\u306e\u540c\u7a2e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u9ac4\u8154\u5185\u6295\u4e0e\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6f5c\u5728\u7684\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Methods\"><\/span>Methods<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672c\u7814\u7a76\u306f\u300112\u304b\u6708\u9593\u306e\u8ffd\u8de1\u671f\u9593\u3092\u8a2d\u3051\u305f\u5358\u7fa4\u30fb\u975e\u76f2\u691c\u30fb\u7b2cI\u76f8\u81e8\u5e8a\u8a66\u9a13\u3068\u3057\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002HUC-MSC\u306f\u30d2\u30c8\u81cd\u5e2f\u7d44\u7e54\u304b\u3089\u62bd\u51fa\u3055\u308c\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u8d85\u9060\u5fc3\u5206\u96e2\u6cd5\u306b\u3088\u3063\u3066\u5358\u96e2\u3055\u308c\u307e\u3057\u305f\u3002\u9ac4\u8154\u5185\u6295\u4e0e\u5f8c\u3001\u5404\u53c2\u52a0\u8005\u306b\u5bfe\u3057\u3066\u5305\u62ec\u7684\u8a55\u4fa1\u304c\u884c\u308f\u308c\u3001American Spinal Injury Association\uff08ASIA\uff09\u30b9\u30b1\u30fc\u30eb\u306b\u3088\u308b\u795e\u7d4c\u5b66\u7684\u8a55\u4fa1\u3001Spinal Cord Independence Measure\uff08SCIM-III\uff09\u306b\u3088\u308b\u6a5f\u80fd\u8a55\u4fa1\u3001Neurogenic Bowel Dysfunction\uff08NBD\uff09\u30b9\u30b3\u30a2\u306b\u3088\u308b\u795e\u7d4c\u56e0\u6027\u8178\u6a5f\u80fd\u969c\u5bb3\u8a55\u4fa1\u3001Modified Ashworth Scale\uff08MAS\uff09\u3001\u304a\u3088\u3073\u4e0b\u90e8\u5c3f\u8def\u6a5f\u80fd\u8cea\u554f\u7968\u306b\u3088\u308b\u8a55\u4fa1\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Results\"><\/span>Results<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5b8c\u5168\u6027\u4e9c\u6025\u6027\u671f\u810a\u9ac4\u640d\u50b7\u60a3\u80059\u540d\u304c\u767b\u9332\u3055\u308c\u307e\u3057\u305f\u3002\u540c\u7a2eHUC-MSC\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u9ac4\u8154\u5185\u6295\u4e0e\u306f\u5b89\u5168\u3067\u3042\u308a\u3001\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u672c\u8a66\u9a13\u4ecb\u5165\u306b\u8d77\u56e0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u65e9\u671f\u307e\u305f\u306f\u5f8c\u671f\u306e\u6709\u5bb3\u4e8b\u8c61\uff08AE\uff09\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001ASIA\u306e\u30d4\u30f3\u30d7\u30ea\u30c3\u30af\u611f\u899a\u30b9\u30b3\u30a2\uff08P\uff1d0.039\uff09\u304a\u3088\u3073\u30e9\u30a4\u30c8\u30bf\u30c3\u30c1\u611f\u899a\u30b9\u30b3\u30a2\uff08P\uff1d0.038\uff09\u3001SCIM-III\u30b9\u30b3\u30a2\u306a\u3069\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%8E%9F%E8%91%97%E6%83%85%E5%A0%B1\"><\/span>\u539f\u8457\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table>\n<thead>\n<tr>\n<th>\u9805\u76ee<\/th>\n<th>\u5185\u5bb9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/td>\n<td>Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial.<\/td>\n<\/tr>\n<tr>\n<td>\u30b8\u30e3\u30fc\u30ca\u30eb<\/td>\n<td>Stem Cell Res Ther<\/td>\n<\/tr>\n<tr>\n<td>\u767a\u8868\u65e5<\/td>\n<td>2024 Aug 26<\/td>\n<\/tr>\n<tr>\n<td>\u8457\u8005<\/td>\n<td>Akhlaghpasand M et al.<\/td>\n<\/tr>\n<tr>\n<td>DOI<\/td>\n<td>10.1186\/s13287-024-03868-0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"HELENE_%E5%8C%BB%E5%B8%AB%E3%81%AE%E8%A6%8B%E8%A7%A3\"><\/span>HELENE \u533b\u5e2b\u306e\u898b\u89e3<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Intrathecal\u3067\u306eExosome\u6295\u4e0e\u306f\u6bd4\u8f03\u7684\u30a2\u30af\u30bb\u30b9\u3057\u3084\u3059\u3044\u6295\u4e0e\u6cd5\u3067\u3042\u308a\u3001\u810a\u9ac4\u640d\u50b7\u60a3\u8005\u306b\u5bfe\u3057\u3066\u5b9f\u65bd\u3057\u3084\u3059\u3044\u65b9\u6cd5\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u9ebb\u75fa\u6539\u5584\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u4eca\u5f8c\u3082\u7d4c\u904e\u3092\u51b7\u9759\u306b\u8a55\u4fa1\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE%E3%83%BB%E9%96%A2%E9%80%A3%E8%B3%87%E6%96%99\"><\/span>\u53c2\u8003\u6587\u732e\u30fb\u95a2\u9023\u8cc7\u6599<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><a href=\"\">PMC\u5168\u6587<\/a>\uff1a<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11346059\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11346059\/<\/a><\/li>\n<\/ul>\n<p><script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"HUC-MSC\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": 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\"\u672c\u7b2cI\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u30019\u540d\u306e\u5b8c\u5168\u6027\u4e9c\u6025\u6027\u671f\u810a\u9ac4\u640d\u50b7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u9ac4\u8154\u5185\u6295\u4e0e\u306b\u304a\u3044\u3066\u3001\u6cbb\u7642\u306b\u8d77\u56e0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u65e9\u671f\u307e\u305f\u306f\u5f8c\u671f\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u5b89\u5168\u6027\u3068\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"\u810a\u9ac4\u640d\u50b7\u306b\u3088\u308b\u9ebb\u75fa\u306e\u6539\u5584\u306f\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u304b\uff1f\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"ASIA\u611f\u899a\u30b9\u30b3\u30a2\u3084SCIM-III\u30b9\u30b3\u30a2\u306a\u3069\u3067\u6709\u610f\u306a\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u75c7\u4f8b\u6570\u304c\u5c11\u306a\u3044\u7b2cI\u76f8\u8a66\u9a13\u3067\u3042\u308b\u305f\u3081\u3001\u9ebb\u75fa\u6539\u5584\u52b9\u679c\u306b\u3064\u3044\u3066\u306f\u4eca\u5f8c\u306e\u5927\u898f\u6a21\u8a66\u9a13\u306b\u3088\u308b\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002\"\n      }\n    }\n  ]\n}\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HELENE CLINIC \u5b66\u8853\u8ad6\u6587\u8981\u7d04\u30b7\u30ea\u30fc\u30ba Safety and potential effects of intrathecal injection of allogeneic human umbilical c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":902,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58,41],"tags":[],"class_list":["post-899","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-58","category-41"],"_links":{"self":[{"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/posts\/899","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/comments?post=899"}],"version-history":[{"count":3,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/posts\/899\/revisions"}],"predecessor-version":[{"id":903,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/posts\/899\/revisions\/903"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/media\/902"}],"wp:attachment":[{"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/media?parent=899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/categories?post=899"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stemcells.jp\/topics\/wp-json\/wp\/v2\/tags?post=899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}