GENOME
Genomic testing
Genomic testing can help you increase your limited time
Do you have any of the following wishes?
☑ I want to know what I will look like in the future
☑ I don't want to make any unnecessary efforts
☑ I'm interested in preventive medicine
By knowing your future risks now while you are healthy, you can reduce your risk of developing disease
Omotesando Helene Clinic's genome testing analyzes all of your genetic information and provides you with customized treatment and improvement methods
What is genomic testing?
Genomic testing is a test that examines the entire genetic information contained in DNA. The purpose is
to propose the most appropriate treatment and improvement method for your constitution and medical condition based on various omics test information, including your individual "genomic information." Diagnosis is made using various medical information, including genomic test results that are guaranteed to be of high quality and reliability, and we provide patients with the most effective treatment, prevention, and onset prediction.
For example, it is said that one in three people in Japan suffers from cancer, and while the term "cancer treatment" generally includes surgery, drug therapy, radiation therapy, and immunotherapy, it also includes chemotherapy, hormone therapy, molecular targeted therapy, and differentiation induction therapy, and there are far more treatments than can be mentioned here, with different drugs and administration methods. Here
, we have used cancer, which is said to be the most common, as an example, but there are certainly several treatments for a variety of diseases, not just cancer, and groping around to find the treatment that is right for you is an extremely difficult task that takes time and money, and could even shorten your precious life.
Finding the best medical treatment and constitution for you based on your genetic information can be life-changing.
That's why genome testing is necessary.
What genetic testing can tell you
Genetic testing at Omotesando Helene Clinic involves two types of testing:
1. Whole Genome Analysis
This test:
1) identifies the presence or absence of disease-related mutations, which can be beneficial for the individual undergoing future medical treatment if the results are known; and
2) reports the presence or absence of mutations that could cause a disease, for those who have family members or relatives with a common disease and are concerned about contracting the same disease
. We
can also analyze other information you want to know from all genomic information.
2. Reveals genetic risk for diseases caused by both genetic and environmental factors.
We analyze 83 disease items, 5 constitutional items, and 3 drug response items, and report results that are important to you. Details are as follows.
Pharyngeal cancer (nasopharyngeal cancer), esophageal cancer (esophageal squamous cell carcinoma), stomach cancer, stomach cancer (scirrhous), stomach cancer (non-cardia gastric cancer), colon cancer, liver cancer (hepatitis B virus), liver cancer (hepatitis C virus), pancreatic cancer, laryngeal cancer (laryngeal squamous cell carcinoma), lung cancer, lung cancer (lung adenocarcinoma), lung cancer (lung squamous cell carcinoma), breast cancer, cervical cancer, ovarian cancer (epithelial), prostate cancer, bladder cancer, brain tumor (neurotumor), thyroid cancer (papillary carcinoma), non-Hodgkin's lymphoma, chronic lymphocytic leukemia
Type 1 diabetes, type 2 diabetes, obesity, gestational diabetes, amyotrophic lateral sclerosis, Parkinson's disease, restless legs syndrome, Alzheimer's disease, epilepsy, migraine, narcolepsy
Age-related macular degeneration, diabetic retinopathy, glaucoma, high myopia, astigmatism, high blood pressure (essential), ischemic heart disease (angina pectoris, myocardial infarction), atrial fibrillation, cerebral infarction (atherothrombotic), cerebral aneurysm, Takayasu's arteritis (aortitis syndrome)
Chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, chronic hepatitis B, chronic hepatitis C, periodontitis, duodenal ulcer, Crohn's disease, ulcerative colitis, cirrhosis (primary biliary cholangitis), cirrhosis (hepatitis C virus), non-alcoholic steatohepatitis
Atopic dermatitis, irritability, male pattern baldness, severe acne, keloids
Rheumatoid arthritis, gout (hyperuricemia), osteoarthritis,
systemic lupus erythematosus, polymyositis/dermatomyositis, Sjogren's syndrome, ankylosing spondylitis, ossification of the posterior longitudinal ligament, lumbar disc degeneration, osteoporosis, IgA nephropathy, nephrotic syndrome, urolithiasis (kidney stones), chronic kidney disease
Graves' disease, thyrotoxic periodic paralysis, uterine fibroids, polycystic ovarian syndrome, double menopause, endometriosis, psychiatric disorders, Behcet's disease
Alcohol decomposition enzymes, alcohol flushing reaction, nicotine addiction, bitter taste perception, salt-sensitive hypertension
CYP2C19, CYP2C9, CYP3A5
Why can we know this from genetic information?
Genetic information, or genomic information, is the "basic blueprint of life."
It consists of approximately 3 billion sequences of the four letters A (adenine), G (guanine), C (cytosine), and T (thymine), and is made up of DNA. The sequence (the arrangement of the letters) was discovered in 2003, and it is now known that the same genomic information exists in all human cells (approximately 60 trillion), and that an individual's genomic information is essentially the same in all 60 trillion cells.
However, when the genome is copied for some reason, replication errors can occur, causing the sequence of letters to be randomly rearranged. These replication errors are related to diseases and other conditions.
Large errors can cause genetic diseases and cancer, while small errors are related to common diseases and physical constitutions. Therefore, by detecting these replication errors through testing, we can learn which diseases you are prone to and determine prevention and treatment methods tailored to your constitution.
Diseases and physical constitutions are not only related to genomic information, but also to environmental factors such as lifestyle habits, so it is not possible to make a general judgment. However, since it is possible to compare the genetic risk of diseases caused by other factors, it is possible to predict the genetic risk of high-risk individuals, and this goes beyond simply being a marker
Why is genomic testing needed now?
At Omotesando Helene Clinic, we believe that the advantage of genetic testing lies in its "prevention."
If you know your genetic information, you can use it to understand risks in advance and find "prevention" that is tailored to you.
Furthermore, since genetic information does not change once it has been tested, the field of genomics, which is attracting global attention, is advancing and will enable even more reliable evaluations.
Features of Helene Clinic's genomic testing
Omotesando
Helene Clinic is that in addition to DNA extraction, we also perform "whole genome" analysis. Because we test for ACMG gene mutations, we are able to report information that would not be revealed through standard genetic testing. Based on this, a specialist will explain the risk of disease from the perspective of genetic factors.
will interpret your genomic information based on your concerns and worries.
If you have any physical concerns or illnesses, we can focus on interpreting them from your genomic information.
A genetic specialist will carefully report each result
, comparing the information from the whole genome analysis with the information you want to know, and will take the time to provide you with the information you need.You will
also receive customized advice based on your results.
Reliability of analysis results
DNA extraction is performed at a facility registered with the Public Health Inspection Center, and DNA analysis is performed at a laboratory certified by CAP, CLIA, ISO, etc. We are constantly improving our methods to increase the accuracy of analysis for East Asians
Inspection flow
1. Please make a reservation at Omotesando Helene Clinic.
2. Based on the medical questionnaire, a specialist will provide counseling and explain the whole genome test.
3. A blood sample will be taken. (Analysis will be performed. This will take approximately one to two months.)
4. The analysis results will be reported to you.
Omotesando Helene Clinic and your promise
Genetic testing is a service that is still relatively unfamiliar in Japan, and we analyze your important information.
Hoping to further advance medical care for the benefit of all, we make the following promises:
1. Security management of personal information
: The data we receive is encrypted and kept anonymous, and stored in a locked vault.
2. Reliability of analysis results:
We use an analysis system that has been carefully examined using all major databases, including ClinVar and OMIM, which collect data from around the world on the relationship between diseases and genes.
3. Solution to long-term medical problems:
We will do our utmost for the health of all.
Q&A About taking the test
At what age can I take genetic testing?
As per our hospital regulations, we are primarily targeting adults
Can a genetic test tell me if I'll go bald in the future?
It can be investigated as a possibility
What are the advantages and disadvantages of genetic testing?
The benefits of this test include being aware of your own physical information, allowing you to take precautions before illness strikes, and potentially preventing illness. Furthermore, since genetic information remains constant, as new research advances, it will be possible to compare your genomic information with new findings. The downside is that
you may learn unfavorable results. These unfavorable results may affect your family members, and some people may not want to know, so it's important not to share your results with others.
I'm unsure whether to have my data analyzed. Is there anything I should understand beforehand?
Depending on the analysis results, you may find some results that are inconvenient for you
